Key Features of SLE


GeneralFatigue, fever, lymphadenopathy, remitting and relapsing illness
SkinMalar (butterfly) rash sparing the nasolabial folds, discoid rash (scaly, erythematous, well-demarcated), photosensitivity, Raynaud’s phenomenon
MusculoskeletalArthralgia, non-erosive arthritis
CardiovascularPericarditis (most common cardiac manifestation), myocarditis
RespiratoryPleurisy, fibrosing alveolitis
RenalProteinuria, glomerulonephritis (diffuse proliferative glomerulonephritis is the most common type)
NeuropsychiatricAnxiety, depression, psychosis, seizures
MouthLarge, multiple, painful mouth ulcers


Diagnostic Tests:


Anti-nuclear antibody (ANA)Most sensitive test for SLE
Anti-dsDNAMost specific test for SLE
Anti-histone antibodiesIndicates drug-induced lupus

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