Drug-Induced Lupus


Common Symptoms:

. Arthralgia

. Myalgia

. Malar rash

. Pleurisy


Laboratory Findings:

i. ANA: Positive in 100%

ii. Anti-dsDNA: Negative

iii. Anti-histone antibodies: Positive in 80-90%


Common Causative Drugs:

i. Procainamide (antiarrhythmic)

ii. Hydralazine (vasodilator for HF and HTN)

iii. Less common: Isoniazid (anti-TB), minocycline, phenytoin



. Discontinue the causative drug: Drug-induced lupus typically resolves on its own after stopping the offending medication.

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